3 x 3 makes sex. Sex-Differential Selection and the Evolution of X Inactivation Strategies.



3 x 3 makes sex

3 x 3 makes sex

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3 x 3 makes sex

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  1. The particular copy of the X that is silenced nevertheless shows considerable variability among species, and the evolutionary causes for this variability remain unclear.

  2. The selective processes that might account for this observed diversity remain unclear. X inactivation strategies can range from strict paternally inherited X inactivation PXI , which renders females haploid for all maternally inherited alleles, to unbiased random X inactivation RXI , which equalizes expression of maternally and paternally inherited alleles in each female tissue. On one of the peak days, she made me call in sick to work and then have sex with her all day.

  3. In both scenarios, the female-deleterious allele is denoted by A 1, i. Evolutionary transitions from PXI to RXI also generally increase mean relative female fitness at the expense of decreased male fitness. The genotype at locus B can influence female fitness through its effect on the relative expression of A 1 versus A 2 alleles in heterozygotes.

  4. To reduce the enormous range of possible fitness parameterizations and initial population conditions, we focus our attention on a subset of idealized and biologically relevant population genetic scenarios in the following analyses.

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